Mary Ann Copenhaver was born about 1780 in Lancaster, Lancaster County, Pennsylvania. She was the daughter of John Thomas Copenhaver (1739-1802) and Catherine Mosser (1739-1777). Mary had at least four siblings: Maria Catherine (born 1760), Christina (born 1761). Thomas (born 1763), and Virginia Elizabeth (born 1772).
Mary Ann Copenhaver married John E Whisman on November 29, 1796, in Wythe County, Virginia. John and Mary had at least eight children over the course of twenty-three years: Elizabeth (born 1800). John Washington (born 1806), Sara Sally (born 1806), Mary K (born 1810), William Michael McCheaf (born 1814), Albion Alvin (born1814), David Crockett (born 1819), and Lavina (born 1823).
Mary Ann died sometime after June 1, 1850, she was about seventy years old. Mary and John had been maried for about fifty-four years.