John E Whisman was born in 1776 in Fincastle, Wythe County, Virginia. John E was the son of John Whisman (1745-1806) and Elizabeth Nye (1745-1806). John E had at least seven siblings: Catherine (born 1765), Henry (born 1767), Phillip (born 1770), Michael (born 1780). Geprge (born 1783), and David (born 1798).
John married Mary Ann Copenhaver on November 29, 1796, in Wythe County, Virginia. John and Mary had at least eight children over the course of twenty-three years: Elizabeth (born 1800). John Washington (born 1806), Sara Sally (born 1806), Mary K (born 1810), William Michael McCheaf (born 1814), Albion Alvin (born 1814), David Crockett (born 1819), and Lavina (born 1823).
John E's wife, Mary Ann, died sometime after June 01, 1850, they had been married at least fifty-four years. John died on March 31, 1857, he was about eight-one years old.